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Two autopsy cases of severe fever with thrombocytopenia syndrome ( SFTS ) in J apan: A pathognomonic histological feature and unique complication of SFTS
Author(s) -
Hiraki Tsubasa,
Yoshimitsu Makoto,
Suzuki Tadaki,
Goto Yuko,
Higashi Michiyo,
Yokoyama Seiya,
Tabuchi Tomohisa,
Futatsuki Takahiro,
Nakamura Kentaro,
Hasegawa Hideki,
Saijo Masayuki,
Kakihana Yasuyuki,
Arima Naomichi,
Yonezawa Suguru
Publication year - 2014
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/pin.12207
Subject(s) - pathognomonic , severe fever with thrombocytopenia syndrome , autopsy , pathology , medicine , immunology , disease , virus
We report two autopsy cases of severe fever with thrombocytopenia syndrome ( SFTS ) with a high fatality rate in aged J apanese patients. Both cases were caused by a tick‐bite. The pathognomonic histological feature was necrotizing lymphadenitis of systemic lymphoid tissue with SFTS viruses and SFTSV‐RNA copies. Marked fungal infections were also observed in the lungs of both patients. Since cellular immune function may be suppressed in SFTS patients, physicians should be aware of possible fungal infections.