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Innocent until proven guilty: mechanisms and roles of S treptococcus– C andida interactions in oral health and disease
Author(s) -
Xu H.,
Jenkinson H.F.,
DongariBagtzoglou A.
Publication year - 2014
Publication title -
molecular oral microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 77
eISSN - 2041-1014
pISSN - 2041-1006
DOI - 10.1111/omi.12049
Subject(s) - candida albicans , microbiology and biotechnology , biofilm , corpus albicans , biology , pathogenesis , pathogen , disease , virulence , immunology , bacteria , medicine , gene , genetics , pathology
Summary Candida albicans and streptococci of the mitis group colonize the oral cavities of the majority of healthy humans. While C. albicans is considered an opportunistic pathogen, streptococci of this group are broadly considered avirulent or even beneficial organisms. However, recent evidence suggests that multi‐species biofilms with these organisms may play detrimental roles in host homeostasis and may promote infection. In this review we summarize the literature on molecular interactions between members of this streptococcal group and C. albicans , with emphasis on their potential role in the pathogenesis of opportunistic oral mucosal infections.