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Associations between osteoporosis and risk of periodontitis: A pooled analysis of observational studies
Author(s) -
Xu Shuai,
Zhang Gang,
Guo Junfeng,
Tan Yinghui
Publication year - 2021
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.13531
Subject(s) - medicine , periodontitis , osteoporosis , observational study , odds ratio , meta analysis , cohort study , confidence interval , population , subgroup analysis , relative risk , dentistry , environmental health
Background Periodontitis and osteoporosis are most popular among aging population and both conditions might be linked, even though, this suggestion still until now debated. Objectives A meta‐analysis on previous investigations has been used to evaluate the correlation between periodontitis and osteoporosis to determine whether osteoporosis is a local indicator of bone loss, or whether it is depending on or related to periodontitis causes. Methods The literature database, including but not excluding, The Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, CINAHL, and Science Citation Index Expanded, was searched in this work during Feb, 2020. We conducted the investigations contain cohort studies, cross‐sectional studies, as well as case–control studies with relative risk (RR) or odds ratio (OR) and 95% confidence intervals (CIs). Subgroup and Sensitivity analysis were also applied to identify heterogeneity sources. Results 23 observational studies with 12 cohorts, 7 cross‐sectional and 4 case–control studies, were included, together with 2,157,037 participants. Osteoporosis patients were more exposed to periodontitis (OR, 1.96; 95% CI, 1.50–2.54). Subgroup analyses showed that the higher risk of osteoporosis in periodontitis patients exists in both cross‐sectional studies (OR, 2.17; 95% CI, 1.80–2.61) and case–control studies (OR 2.63; 95% CI, 1.69–4.09), and marginally in cohort studies (OR, 1.70; 95% CI, 1.16–2.49). Conclusion Review analyses have shown that osteoporosis is closely related to the increased risk of periodontitis in the future. Dental specialists better to understand the potential association between periodontitis and osteoporosis.