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Western lifestyle and immunopathology of multiple sclerosis
Author(s) -
Matveeva Olga,
Bogie Jeroen F.J.,
Hendriks Jerome J.A.,
Linker Ralf A.,
Haghikia Aiden,
Kleinewietfeld Markus
Publication year - 2018
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/nyas.13583
Subject(s) - multiple sclerosis , pathogenesis , medicine , incidence (geometry) , environmental health , immunology , optics , physics
There is increasing evidence for a sudden and unprecedented rise in the incidence of multiple sclerosis (MS) in Westernized countries over the past decades, emphasizing the role of environmental factors. Among many candidates, rapid changes in dietary habits seem to play a role in the pathogenesis of MS. Here, we summarize and discuss the available evidence for the role of dietary nutrients, such as table salt, fatty acids, and flavonoids, in the development and pathogenesis of MS. We also discuss new and emerging risk factors accompanying Western lifestyle, such as shift work, sleep, and circadian disruption.