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Two phylogenetically unrelated peptide‐receptor modules jointly regulate lateral root initiation via a partially shared signaling pathway in Arabidopsis thaliana
Author(s) -
Jourquin Joris,
Fernandez Ana Ibis,
Parizot Boris,
Xu Ke,
Grunewald Wim,
Mamiya Akihito,
Fukaki Hidehiro,
Beeckman Tom
Publication year - 2022
Publication title -
new phytologist
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.742
H-Index - 244
eISSN - 1469-8137
pISSN - 0028-646X
DOI - 10.1111/nph.17919
Subject(s) - biology , wrky protein domain , microbiology and biotechnology , arabidopsis , signal transduction , arabidopsis thaliana , lateral root , receptor , function (biology) , phosphorylation , transcription factor , phenotype , genetics , gene , mutant
Summary Peptide‐receptor signaling is an important system for intercellular communication, regulating many developmental processes. A single process can be controlled by several distinct signaling peptides. However, since peptide‐receptor modules are usually studied separately, their mechanistic interactions remain largely unexplored. Two phylogenetically unrelated peptide‐receptor modules, GLV6/GLV10‐RGI and TOLS2/PIP2‐RLK7, independently described as inhibitors of lateral root initiation, show striking similarities between their expression patterns and gain‐ and loss‐of‐function phenotypes, suggesting a common function during lateral root spacing and initiation. The GLV6/GLV10‐RGI and TOLS2/PIP2‐RLK7 modules trigger similar transcriptional changes, likely in part via WRKY transcription factors. Their overlapping set of response genes includes PUCHI and PLT5 , both required for the effect of GLV6/10, as well as TOLS2, on lateral root initiation. Furthermore, both modules require the activity of MPK6 and can independently trigger MPK3/MPK6 phosphorylation. The GLV6/10 and TOLS2/PIP2 signaling pathways seem to converge in the activation of MPK3/MPK6, leading to the induction of a similar transcriptional response in the same target cells, thereby regulating lateral root initiation through a (partially) common mechanism. Convergence of signaling pathways downstream of phylogenetically unrelated peptide‐receptor modules adds an additional, and hitherto unrecognized, level of complexity to intercellular communication networks in plants.