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Plant 3D genomics: the exploration and application of chromatin organization
Author(s) -
Pei Liuling,
Li Guoliang,
Lindsey Keith,
Zhang Xianlong,
Wang Maojun
Publication year - 2021
Publication title -
new phytologist
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.742
H-Index - 244
eISSN - 1469-8137
pISSN - 0028-646X
DOI - 10.1111/nph.17262
Subject(s) - chromatin , chromosome conformation capture , computational biology , genomics , genomic organization , genome , biology , evolutionary biology , spatial organization , functional genomics , structural genomics , genetics , dna , gene , protein structure , transcription factor , biochemistry , enhancer
Summary Eukaryotic genomes are highly folded for packing into higher‐order chromatin structures in the nucleus. With the emergence of state‐of‐the‐art chromosome conformation capture methods and microscopic imaging techniques, the spatial organization of chromatin and its functional implications have been interrogated. Our knowledge of 3D chromatin organization in plants has improved dramatically in the past few years, building on the early advances in animal systems. Here, we review recent advances in 3D genome mapping approaches, our understanding of the sophisticated organization of spatial structures, and the application of 3D genomic principles in plants. We also discuss directions for future developments in 3D genomics in plants.