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Synthetic biology of hypoxia
Author(s) -
Licausi Francesco,
Giuntoli Beatrice
Publication year - 2021
Publication title -
new phytologist
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.742
H-Index - 244
eISSN - 1469-8137
pISSN - 0028-646X
DOI - 10.1111/nph.16441
Subject(s) - synthetic biology , biology , hypoxia (environmental) , computational biology , plant biology , oxygen , biochemical engineering , microbiology and biotechnology , chemistry , botany , organic chemistry , engineering
Summary Synthetic biology can greatly aid the investigation of fundamental regulatory mechanisms and enable their direct deployment in the host organisms of choice. In the field of plant hypoxia physiology, a synthetic biology approach has recently been exploited to infer general properties of the plant oxygen sensing mechanism, by expression of plant‐specific components in yeast. Moreover, genetic sensors have been devised to report cellular oxygen levels or physiological parameters associated with hypoxia, and orthogonal switches have been introduced in plants to trigger oxygen‐specific responses. Upcoming applications are expected, such as genetic tailoring of oxygen‐responsive traits, engineering of plant hypoxic metabolism and oxygen delivery to hypoxic tissues, and expansion of the repertoire of genetically encoded oxygen sensors.