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Dogs are reservoir hosts of leishmaniasis caused by  Leishmania infantum  and transmitted by phlebotomine vectors. The effect of dinotefuran, pyriproxyfen and permethrin spot‐on solution (Vectra®3D, Ceva Santé Animale, Libourne, France) on  Leishmania  transmissibility by naturally infected dogs via reared  Phlebotomus perniciosus , was assessed. Dogs affected by leishmaniasis were submitted to xenodiagnosis and 6 infecting >10% of insects were treated topically on day 0. Antifeeding, insecticidal and anti‐transmissibility effects were evaluated through xenodiagnoses performed on days 1, 7 and 28, using individual pre‐treatment parameters as control. Feeding and mortality rates were assessed at 24 h, whereas promastigote infection, maturation and burden were assessed up to 96 h post blood meal (potentially infectious rate). On day 1, the anti‐feeding efficacy was >95% in 4 dogs, insecticidal efficacy 100% in 4 dogs, and anti‐transmissibility effect 100% in 6 dogs. Efficacy rates recorded on day 7 were very similar to day 1. On day 28, anti‐feeding and insecticidal efficacy values were much broader, ranging 32.6–100% and 7.7–94.4%, respectively. Potentially infectious insects were recorded from two dogs, with sharp decrease in transmissibility rate as compared with pre‐treatment condition. Altogether, Vectra®3D abrogated by >98% the potential  Leishmania  transmissibility by the examined pool of infected dogs over 1 month.

Laboratory evidence that dinotefuran, pyriproxyfen and permethrin combination abrogates Leishmania infantum transmissibility by sick dogs