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The pathogenesis of the rice pathogenic bacterium  Burkholderia glumae  is under the tight regulation of the  tofI / tofR  quorum‐sensing (QS) system.  tepR , encoding a group I bacterial enhancer‐binding protein, negatively regulates the production of toxoflavin, the phytotoxin acting as a major virulence factor in  B. glumae . In this study, through a transcriptomic analysis, we identified the genes that were modulated by  tepR  and/or the  tofI / tofR  QS system. More than half of the differentially expressed genes, including the genes for the biosynthesis and transport of toxoflavin, were significantly more highly expressed in the Δ tepR  mutant but less expressed in the Δ tofI‐tofR  ( tofI / tofR  QS‐defective) mutant. In consonance with the transcriptome data, other virulence‐related functions of  B. glumae , extracellular protease activity and flagellum‐dependent motility, were also negatively regulated by  tepR , and this negative regulatory function of  tepR  was dependent on the IclR‐type transcriptional regulator gene  qsmR . Likewise, the Δ tepR  mutant exhibited a higher level of heat tolerance in congruence with the higher transcription levels of heat shock protein genes in the mutant. Interestingly,  tepR  also exhibited its positive regulatory function on a previously uncharacterized type VI secretion system (denoted as BgT6SS‐1). The survival of the both Δ tepR  and Δ tssD  (BgT6SS‐1‐defective) mutants was significantly compromised compared to the wild‐type parent strain 336gr‐1 in the presence of the natural rice‐inhabiting bacterium,  Pantoea  sp. RSPAM1. Taken together, this study revealed pivotal regulatory roles of  tepR  in orchestrating multiple biological functions of  B. glumae , including pathogenesis, heat tolerance, and bacterial interspecies competition.

molecular plant pathology

tepR  encoding a bacterial enhancer‐binding protein orchestrates the virulence and interspecies competition of  Burkholderia glumae  through  qsmR  and a type VI secretion system