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Summary  The human fungal pathogen   C   andida albicans  undergoes white‐opaque phenotypic switching, which enhances its adaptation to host niches. Switching is controlled by a transcriptional regulatory network of interlocking feedback loops acting on the transcription of   WOR   1 , the master regulator of white‐opaque switching, but regulation of the network on the translational level is not yet explored. Here, we show that the long 5′ untranslated region of   WOR   1  regulates the white‐opaque phenotype. Deletion of the   WOR   1  5′  UTR  promotes white‐to‐opaque switching and stabilizes the opaque state. The   WOR   1  5′  UTR  reduces translational efficiency and the association of the transcript with polysomes. Reduced polysome association was observed for additional key regulators of cell fate and morphology with long 5′  UTR  as well. Overall, we find a novel regulatory step of white‐opaque switching at the translational level. This translational regulation is implicated for many key regulators of cell fate and morphology in   C   . albicans .

The WOR 1 5′ untranslated region regulates white‐opaque switching in C andida albicans by reducing translational efficiency