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Background & Aims   HCV  Council 2014, like its predecessor  HCV  Council 2011, assembled leading clinicians and researchers in the field of hepatitis C to critically evaluate current data regarding best practices for managing patients with chronic hepatitis C virus ( HCV ).    Methods  Clinical practice statements were developed that reflect the areas of potential controversy with high clinical impact. Faculty members were responsible for reviewing the literature to support or reject these statements. After a review and comprehensive discussion of the data, the  HCV  Council faculty voted on the nature of the evidence and the level of support for each statement.    Results  The results of the detailed analysis with expert opinion are summarized in this article.    Conclusion  Numerous questions regarding optimal management of certain populations and clinical scenarios remain unanswered. The discussion in the article provides a summary of evidenced‐based expert opinion that may help guide clinicians as additional information is developed.

HCV Council – critical appraisal of data: recommendations for clinical practice in a rapidly evolving therapeutic landscape