Open AccessAssociation between hyperlipidemia and calcium oxalate lower urinary tract uroliths in dogs
Author(s) -
Paulin Mathieu V,
Dunn Marilyn,
Vachon Catherine,
Beauchamp Guy,
Conversy Bérénice
Publication year - 2021
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/jvim.16324
Subject(s) - medicine , hyperlipidemia , odds ratio , urinary system , gastroenterology , triglyceride , obesity , uric acid , univariate analysis , urine , cholesterol , endocrinology , diabetes mellitus , multivariate analysis
Background Metabolic syndrome is associated with formation of calcium oxalate (CaOx) uroliths in humans. Objectives To investigate the association between obesity and hyperlipidemia with CaOx lower urinary tract uroliths in client‐owned dogs. Animals Dogs with (n = 55, U [uroliths]‐dogs) and without (n = 39, UF [uroliths‐free]‐dogs) CaOx lower urinary tract uroliths. Methods Case‐control study. U‐dogs were retrospectively enrolled and compared to UF‐dogs. Body condition score (BCS; 1‐9 scoring scale), serum triglyceride (TG) and total cholesterol (CH) concentrations and glycemia (after >12‐hour food withholding) were recorded in both groups. Results On univariate logistic regression, when excluding Miniature Schnauzers, odds of having uroliths increased by a factor of 3.32 (95% CI 1.38‐11.12) for each mmol/L of TG ( P = .027), of 39 (95% CI 9.27‐293.22) for each mmol/L of glycemia ( P < .0001), and of 2.43 (95% CI 1.45‐4.45) per unit of BCS ( P = .002). In multivariable models, the effect of TG was retained when all breeds were included for analysis and odds of having uroliths increased by a factor of 4.34 per mmol/L of TG (95% CI 1.45‐19.99; P = .02). Conclusions and Clinical Importance Serum lipid screening in dogs diagnosed with CaOx uroliths might be recommended to improve their medical staging and management.