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Background  Urinary tract infections (UTIs) are common in dogs and can be caused by multidrug‐resistant  Escherichia coli  ( E coli ).    Objective  To describe the frequency and mechanisms of antimicrobial resistance (AMR) among  E coli  causing UTIs in dogs in Western Canada during a 4‐year surveillance period.    Animals  Urine from 516 dogs.    Methods  From November 2014 to 2018, 516 nonduplicate  E coli  isolates from the urine of dogs were collected from a diagnostic laboratory. Susceptibility testing was determined for a panel of 14 antimicrobials belonging to 7 drug classes. Resistant isolates were screened for the presence of extended‐spectrum beta‐lactamases (ESBLs), AmpC β‐lactamases, and plasmid‐mediated quinolone resistance (PMQR) genes. Epidemiological relationships were assessed by MLST.    Results  80.2% (414/516) of isolates were susceptible to all antimicrobials tested. There was no significant increase in the proportion of isolates resistant to any of the tested antimicrobials during the study period. Resistance to ampicillin was the most common (14.9%, 77/516). Overall, 12 isolates had  bla  CMY‐2 ‐type AmpC β‐lactamases, and 7 produced CTX‐M‐type ESBLs. A single isolate had the  aac(6′)‐Ib‐cr  PMQR gene. The  qnr  and  qep A determinants were not detected. A single isolate belonging to the pandemic lineage ST131 was identified.    Conclusion   Escherichia coli  isolated from the urine of dogs in our region remain susceptible to first‐line therapies, though resistance, particularly to the aminopenicillins, warrants monitoring. This is the first description of  E coli  ST131 from a companion animal in Canada.

journal of veterinary internal medicine

Characterization of antimicrobial‐resistant   Escherichia coli   causing urinary tract infections in dogs: Passive surveillance in Saskatchewan, Canada 2014 to 2018