Open AccessAventriculi associated with holoprosencephaly in a dog
Author(s) -
Barnard Laura,
Durand Alexane,
Blume Lauren,
Lee Laura,
Cameron Starr
Publication year - 2020
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/jvim.15907
Subject(s) - holoprosencephaly , medicine , ventricular system , third ventricle , choroid plexus , magnetic resonance imaging , histopathology , ventriculomegaly , anatomy , lateral ventricles , autopsy , hydrocephalus , german shepherd dog , subarachnoid space , computed tomographic , radiology , pathology , computed tomography , central nervous system , cerebrospinal fluid , pregnancy , fetus , genetics , biology
Case Description A 10‐month‐old neutered male mixed breed dog was presented for assessment of poorly controlled seizures. Clinical Findings Magnetic resonance imaging of the brain disclosed complete absence of the lateral and third ventricles and mesencephalic aqueduct. Postmortem computed tomographic (CT) imaging and positive contrast cisterno‐ventriculography confirmed the lack of a contiguous ventricular system. However, histopathology identified the presence of vestigial lateral and third ventricles with hypoplastic choroid plexus, atresia of the third ventricle, and fused thalami, consistent with a diagnosis of lobar holoprosencephaly (HPE). Clinical Relevance To our knowledge, this report is the first case of radiographically confirmed aventriculi associated with HPE, a rare congenital malformation previously reported in people, to be described in veterinary medicine.