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Background  Concerns for recrudescence of  Ehrlichia canis  infection arise when immunosuppressive drugs are used to treat immune‐mediated diseases in dogs previously infected with   E. canis .Objectives  Determine whether administration of prednisolone and cyclosporine would reactivate   E. canis   infection in dogs previously treated with doxycycline during the acute or subclinical phases.    Animals  Seven beagles previously experimentally infected with   E. canis   and administered doxycycline for 4 weeks were included. Three of the 7 dogs were incidentally concurrently infected with  Anaplasma platys  and  Babesia vogeli  and were administered 2 doses of imidocarb 2 weeks apart before enrollment in the current study.    Methods  Experimental study. Each dog was administered prednisolone and cyclosporine for 6 weeks. Clinical signs, complete blood cell count (CBC), polymerase chain reaction (PCR) assays for   E. canis  ,  A. platys , and  B. vogeli  DNA in blood,   E. canis   indirect fluorescent antibodies (IFA) titers, and flow cytometry for antiplatelet antibodies were monitored.    Results  All dogs completed the immunosuppressive protocol. No evidence for recrudescence of   E. canis  ,  A. platys , or  B. vogeli  were detected based on clinical signs or results of CBC, PCR, IFA, and flow cytometry for antiplatelet antibodies.  E. canis  IFA titers were negative in 5/7 dogs at the end of immunosuppressive protocol and were negative 6 months after the protocol in 5/5 dogs available for testing.    Conclusions and Clinical Importance  Dogs administered with a 4‐week course of doxycycline with or without imidocarb failed to show evidence of activation of   E. canis   infection after administration of a commonly used immune suppressive protocol.

Ehrlichia canis in dogs experimentally infected, treated, and then immune suppressed during the acute or subclinical phases