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Background  Salmonellosis is a major cause of morbidity and mortality in neonatal calves, often occurring before preventative vaccines can be administered.    Hypothesis/Objective  To evaluate the protective effect on calves of colostrum from cows vaccinated with a commercially available  Salmonella  Newport bacterin against a  Salmonella  Typhimurium challenge.    Animals  Twenty Holstein bull calves from a university dairy farm.    Methods  Nonrandomized placebo‐controlled trial in which colostrum was harvested from 30 cows that received 2 doses of either  Salmonella  bacterin or saline before calving. Colostrum collected from each group was pooled and fed to 2 groups of 10 calves at birth. At approximately 2 weeks of age, calves were challenged with  Salmonella  Typhimurium. Clinical, hematologic, microbiological, and postmortem findings were compared between the 2 groups.    Results  No differences in mortality, clinical findings, hematology results, blood and fecal cultures, or necropsy findings between the 2 groups were observed. Vaccinated cows had higher colostral titers, and calves fed this colostrum had higher serum titers (mean difference, 0.429; mean [SE], 0.852 [0.02] for vaccinated versus 0.423 [0.02] for control calves).    Conclusions and Clinical Importance  Transfer of colostral immunoglobulins from  Salmonella enterica  serotype Newport bacterin to neonatal calves was not sufficient to decrease mortality, clinical signs, sepsis, intestinal damage, or fecal shedding when exposed to a highly pathogenic  Salmonella  isolate. A large‐scale randomized controlled clinical trial is needed to evaluate the efficacy of this bacterin when administered in the dry period for prevention of salmonellosis in neonatal calves.

journal of veterinary internal medicine

Exploratory cohort study to determine if dry cow vaccination with a  Salmonella  Newport bacterin can protect dairy calves against oral  Salmonella  challenge