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Background  T‐zone lymphoma (TZL), an indolent disease in older dogs, comprises approximately 12% of lymphomas in dogs. TZL cells exhibit an activated phenotype, indicating the disease may be antigen‐driven. Prior research found that asymptomatic aged Golden Retrievers (GLDRs) commonly have populations of T‐zone‐like cells (phenotypically identical to TZL) of undetermined significance (TZUS).    Objective  To evaluate associations of inflammatory conditions, TZL and TZUS, using a case‐control study of GLDRs.    Animals  TZL cases (n = 140), flow cytometrically diagnosed, were identified through Colorado State University's Clinical Immunology Laboratory. Non‐TZL dogs, recruited through either a database of owners interested in research participation or the submitting clinics of TZL cases, were subsequently flow cytometrically classified as TZUS (n = 221) or control (n = 147).    Methods  Health history, signalment, environmental, and lifestyle factors were obtained from owner‐completed questionnaires. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were estimated using multivariable logistic regression, obtaining separate estimates for TZL and TZUS (versus controls).    Results  Hypothyroidism (OR, 0.3; 95% CI, 0.1‐0.7), omega‐3 supplementation (OR, 0.3; 95% CI, 0.1‐0.6), and mange (OR, 5.5; 95% CI, 1.4‐21.1) were significantly associated with TZL. Gastrointestinal disease (OR, 2.4; 95% CI, 0.98‐5.8) had nonsignificantly increased TZL odds. Two shared associations for TZL and TZUS were identified: bladder infection or calculi (TZL OR, 3.5; 95% CI, 0.96‐12.7; TZUS OR, 5.1; 95% CI, 1.9‐13.7) and eye disease (TZL OR, 2.3; 95% CI, 0.97‐5.2; TZUS OR, 1.9; 95% CI, 0.99‐3.8).    Conclusions and Clinical Importance  These findings may elucidate pathways involved in TZUS risk and progression from TZUS to TZL. Further investigation into the protective association of omega‐3 supplements is warranted.

journal of veterinary internal medicine

Associations of environment, health history, T‐zone lymphoma, and T‐zone‐like cells of undetermined significance: A case‐control study of aged Golden Retrievers