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Background  Cobalt chloride (CoCl 2 ) is administered to racehorses to enhance performance. The purpose of this study was to evaluate the clinical, cardiovascular, and endocrine effects of parenterally administered CoCl 2 .    Objectives  To describe the effects of weekly intravenous doses of CoCl 2  on Standardbred horses.    Animals  Five, healthy Standardbred mares.    Methods  Prospective, randomized, experimental dose‐escalation pilot. Five Standardbred mares were assigned to receive 1 of 5 doses of CoCl 2  (4, 2, 1, 0.5, or 0.25 mg/kg) weekly  IV  for 5 weeks. Physical examination, blood pressure, cardiac output, and electrocardiography ( ECG ) were evaluated for 4 hours after administration of the first and fifth doses. Blood and urine samples were collected for evaluation of cobalt concentration,  CBC  and clinical chemistry, and hormone concentrations.    Results  All mares displayed pawing, nostril flaring, muscle tremors, and straining after CoCl 2  infusion. Mares receiving 4, 2, or 1 mg/kg doses developed tachycardia after dosing ( HR  60–126 bpm). Ventricular tachycardia was noted for 10 minutes after administration of the 4 mg/kg dose. Increases in systolic arterial pressure ( SAP ), diastolic arterial pressure ( DAP ), and mean arterial pressure ( MAP ) occurred after administration of all doses (4, 2, 1, 0.5, and 0.25 mg/kg). Profound hypertension was observed after the 4 mg/kg dose ( SAP / DAP ,  MAP  [mmHg] = 291–300/163–213, 218–279). Hemodynamics normalized by 1–2 hours after administration.  ACTH  and cortisol concentrations increased within 30 minutes of administration of all CoCl 2  doses, and cardiac troponin I concentration increased after administration of the 4 and 2 mg/kg doses.    Conclusions and Clinical Importance  The degree of hypertension and arrhythmia observed after  IV  CoCl 2  administration raises animal welfare and human safety concerns.

Effect of Intravenous Administration of Cobalt Chloride to Horses on Clinical and Hemodynamic Variables