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Background  Although continuous digital hypothermia ( CDH ) protects lamellae from injury in the oligofructose ( OF ) model of sepsis‐related laminitis ( SRL ), conflicting results exist from these studies regarding effects of  CDH  on lamellar inflammatory events.    Hypothesis/Objectives  To determine the effect of  CDH  on lamellar inflammatory events in normal and  OF ‐treated horses when instituted at a clinically relevant time point (onset of clinical signs of sepsis in this model).    Animals  Standardbred geldings (n = 15) aged 3–11 years were used.    Methods  In a randomized, controlled discovery study, animals were administered either  OF  ( OF  group, n = 8) or water ( CON  group, n = 8) by nasogastric tube and  CDH  was initiated in one forelimb ( ICE ) 12 hours later. Lamellar tissue samples were collected 24 hours after initiation of  CDH  ( ICE  and ambient [ AMB ] forelimbs). Lamellar  mRNA  concentrations of inflammatory mediators and lamellar leukocyte numbers were assessed using  qPCR  and immunohistochemistry, respectively; values from four sample groups ( CON AMB ,  OF AMB ,  CON ICE , and  OF ICE ) were analyzed using mixed model linear regression.    Results  Although lamellar  mRNA  concentrations of multiple inflammatory mediators ( IL ‐1β,  IL ‐6,  CXCL 1,  MCP 2,  COX ‐2) were increased after  OF  administration ( OF AMB  group versus  CON AMB ;  P  < 0.05), only 2 inflammatory mediators ( IL ‐6 and  COX ‐2) and lamellar leukocyte numbers were decreased with  CDH  ( OF ICE  versus  OF AMB ;  P  < 0.05).    Conclusions and Clinical Importance  Continuous digital hypothermia initiated at a time point similar to that commonly used clinically (clinical onset of sepsis) resulted in a more focused inhibition of inflammatory signaling.

journal of veterinary internal medicine

Effect of Continuous Digital Hypothermia on Lamellar Inflammatory Signaling When Applied at a Clinically‐Relevant Timepoint in the Oligofructose Laminitis Model