Open AccessCardiac Troponin I and Amino‐Terminal Pro B‐Type Natriuretic Peptide in Dogs With Stable Chronic Kidney Disease
Author(s) -
Pelander L.,
Häggström J.,
Ley C.J.,
Ljungvall I.
Publication year - 2017
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/jvim.14703
Subject(s) - medicine , azotemia , natriuretic peptide , troponin i , urinalysis , renal function , cardiology , kidney disease , blood pressure , heart failure , endocrinology , urinary system , gastroenterology , myocardial infarction
Background Increased concentrations of N‐terminal pro B‐type natriuretic peptide ( NT ‐pro BNP ) and cardiac troponin I ( cTnI ) in dogs with azotemia have been documented. Knowledge of mechanisms behind increased concentrations of cardiac biomarkers in dogs with azotemia is warranted for correct interpretation of test results. Objectives The aim of the article was to investigate possible associations between plasma concentrations of cTnI and NT ‐pro BNP , respectively, and patient characteristics, glomerular filtration rate ( GFR ), a plasma volume factor (PVF) derived from scintigraphic examination ( PV f), systolic blood pressure ( SBP ), selected hematologic and biochemical variables, and echocardiographic measurements in dogs with stable chronic kidney disease ( CKD ) and in healthy dogs. Animals Fifty student‐, staff‐, and client‐owned dogs were included. Twenty‐three of the dogs were healthy and 27 were diagnosed with CKD . Methods In this cross‐sectional observational study, dogs with a previous diagnosis of CKD and healthy control dogs were included. At inclusion, all dogs were characterized by physical examination, repeated blood pressure measurements, complete urinalysis, hematology and biochemistry panel, echocardiography, abdominal ultrasound examination of the entire urinary tract, and scintigraphic examination for measurement of GFR . Results Plasma volume factor and PCV were independently associated with NT ‐pro BNP ( R adj 2 = 0.42; P < .0001). Age, body weight ( BW ), and SBP were independently associated with cTnI ( R adj 2 = 0.50; P < .0001). Conclusions and Clinical Importance Neither NT ‐pro BNP nor cTnI concentrations were independently associated with measured GFR . Thus, findings were not suggestive of passive accumulation of either marker, suggesting that increased circulating concentrations of cTnI and NT ‐pro BNP can be interpreted similarly in dogs with stable CKD as in dogs without CKD.