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Background  Diagnosis of protein loss into the gastrointestinal tract using noninvasive techniques is challenging. In people, scintigraphy not only is a sensitive tool to confirm protein‐losing enteropathy ( PLE ), but it also allows for localization of protein loss.    Hypothesis/Objectives  To investigate the feasibility of  99m Tc‐labeled human serum albumin ( HSA ) scintigraphy in dogs with  PLE  in comparison with control dogs.    Animals  A total of 8 clinically healthy control research dogs and 7 client‐owned dogs with gastrointestinal clinical signs and hypoalbuminemia (serum albumin concentration <2.0 g/dL).    Methods  Prospective case–control study. After  IV  injection of 400 MBq freshly prepared  99m Tc  HSA  (30 mg/dog), images of the abdomen were obtained 10, 60, 120, and 240 minutes postinjection. Additional images of the salivary and thyroid glands were obtained to rule out free  99m Tc. A scan was considered positive for  PLE  when radiopharmaceutical exudation was detectable in the intestinal tract.    Results  Only 1 control dog showed exudation of the radiopharmaceutical into the intestinal tract. No free  99m Tc was detected in any dog. In dogs with  PLE , focal small intestinal and diffuse small intestinal radiopharmaceutical exudation into the bowel was detected in 2 and 3 dogs, respectively, whereas in 2 dogs, there was disagreement about whether radiopharmaceutical exudation was focal or diffuse.    Conclusion and Clinical Importance   99m Tc‐labeled  HSA  scintigraphy was feasible to diagnose  PLE  in dogs.

Applicability of 99m Tc‐Labeled Human Serum Albumin Scintigraphy in Dogs With Protein‐Losing Enteropathy