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Background  Famotidine is an acid suppressant commonly administered to dogs. Prolonged famotidine use in people results in decreased efficacy, but the effect in dogs is unknown.    Hypothesis/Objectives  To compare the effect of repeated oral administration of famotidine or placebo on intragastric  pH  and serum gastrin in dogs. We hypothesized that famotidine would have a diminished effect on intragastric  pH  on day 13 compared to day 1.    Animals  Six healthy adult colony Beagles.    Methods  Randomized, 2‐factor repeated‐measures crossover design. All dogs received oral placebo or 1.0 mg/kg famotidine q12h for 14 consecutive days. Intragastric  pH  monitoring was used to continuously record intragastric  pH  on treatment days 1–2 and 12–13. Mean  pH  as well as mean percentage time ( MPT ) that intragastric  pH  was ≥3 or ≥4 were compared between and within groups by analysis of variance. Serum gastrin was measured on days 0, 3, and 12 for each treatment.    Results  Continued administration of famotidine resulted in a significant decrease in mean  pH ,  MPT  ≥3, and  MPT  ≥4 ( P  < .0001) on day 12 and 13. This resulted in a mean decrease in  pH  by 1.63 on days 12 and 13 compared to days 1 and 2. Furthermore, a mean decrease of  MPT  ≥3 and  MPT  ≥4 by 33 and 45% was observed for the same time period, respectively.    Conclusions and Clinical Importance  Continued administration of famotidine results in a diminished effect on intragastric  pH  in dogs. Caution is advised when recommending long‐term, daily oral administration of famotidine to dogs.

Repeated Famotidine Administration Results in a Diminished Effect on Intragastric pH in Dogs