Open AccessAminoaciduria Caused by Fanconi Syndrome in a Heifer
Author(s) -
Cesbron N.,
Dorso L.,
Royer A.L.,
DervillyPinel G.,
Hervé J.
Publication year - 2017
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/jvim.14605
Subject(s) - aminoaciduria , fanconi syndrome , medicine , glycosuria , hypochloremia , hyperuricosuria , proteinuria , hypokalemia , urinalysis , hypophosphatemia , pathology , azotemia , tubulopathy , gastroenterology , hyponatremia , endocrinology , kidney , urine , hypercalciuria , renal function , diabetes mellitus
A case study of renal tubular dysfunction consistent with idiopathic Fanconi syndrome is reported in an 18‐month‐old Holstein heifer. The clinical, biochemical, and histopathological features are described. The heifer had clinical signs of growth retardation, wasting, and persistent diarrhea. Biochemical blood analysis identified hypokalemia, hyponatremia, and hypochloremia. Urinalysis identified glycosuria, proteinuria, and acidic pH . Histological examination of the kidney disclosed mild tubular necrosis with proteinaceous casts in the lumina of renal tubules. We performed LC ‐ HRMS on urine to confirm Fanconi syndrome. Using this technique, we identified severe generalized aminoaciduria suggestive of idiopathic renal Fanconi syndrome in this heifer.