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Background  Deletion of exon 2 of  copper metabolism domain containing 1  (  COMMD 1 ) results in copper toxicosis in Bedlington terriers ( CT ‐ BT ).    Objectives  This study was conducted to identify the prevalence and clinical relevance of the   COMMD 1  mutation in Bedlington terriers in Korea.    Animals  A total of 105 purebred Bedlington terriers (50 males, 55 females) from the kennels and pet dog clubs in Korea were examined during the period 2008–2013.    Methods  A multiplex  PCR  was carried out to detect exon 2 deletion of   COMMD 1 . Clinical analysis was performed on each genetic group, and clinical status of the dogs was followed up to estimate survival probability.    Results  Of the 105 samples, 52 (49%) were wild‐type homozygote, 47 (45%) were heterozygote, and 6 (6%) were mutant‐type homozygote. Plasma alanine aminotransferase ( ALT ) activity was increased in the mutant‐type homozygous group >2 years of age ( P  < .0001). The survival probability of 6 mutant‐type homozygotes surviving 2.5 years was 0.67, and 4 years was 0.5.    Conclusions and Clinical Importance  Results show the prevalence and clinical relevance of exon 2 deletion of   COMMD 1  and could help establish a structured selective breeding program to prevent  CT ‐ BT  in Korea.

Prevalence and Clinical Relevance of Exon 2 Deletion of COMMD 1 in Bedlington Terriers in Korea