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Background  Clopidogrel is commonly prescribed to cats with perceived increased risk of thromboembolic events, but little information exists regarding its antiplatelet effects.    Objective  To determine effects of clopidogrel on platelet responsiveness in cats with or without the A31P mutation in the   MYBPC 3  gene. A secondary aim was to characterize variability in feline platelet responses to clopidogrel.    Animals  Fourteen healthy cats from a Maine Coon/outbred mixed Domestic cat colony: 8 cats homozygous for A31P mutation in the   MYPBC 3  gene and 6 wild‐type cats without the A31P mutation.    Methods  Ex vivo study. All cats received clopidogrel (18.75 mg  PO  q24h) for 14 days. Before and after clopidogrel treatment, adenosine diphosphate ( ADP )‐induced P‐selectin expression was evaluated.  ADP ‐ and thrombin‐induced platelet aggregation was measured by optical aggregometry ( OA ). Platelet  pVASP  and  ADP  receptor response index ( ARRI ) were measured by Western blot analysis.    Results  Platelet activation from cats with the A31P mutation was significantly ( P  = .0095) increased [35.55% (18.58–48.55) to 58.90% (24.85–69.90)], in response to  ADP . Clopidogrel treatment attenuated  ADP ‐induced P‐selectin expression and platelet aggregation.  ADP ‐ and  PGE  1 ‐treated platelets had a similar level of  pVASP  as  PGE  1 ‐treated platelets after clopidogrel treatment. Clopidogrel administration resulted in significantly lower  ARRI  [24.13% (12.46–35.50) to 11.30% (−7.383 to 23.27)] ( P  = .017). Two of 13 cats were nonresponders based on  OA  and flow cytometry.    Conclusion and Clinical Importance  Clopidogrel is effective at attenuating platelet activation and aggregation in some cats. Cats with A31P mutation had increased platelet activation relative to the variable response seen in wild‐type cats.

Platelet Activation and Clopidogrel Effects on ADP ‐Induced Platelet Activation in Cats with or without the A31P Mutation in MYBPC 3