Open AccessSerum Cystatin C Concentrations in Cats with Hyperthyroidism and Chronic Kidney Disease
Author(s) -
Williams T.L.,
Dillon H.,
Elliott J.,
Syme H.M.,
Archer J.
Publication year - 2016
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/jvim.13956
Subject(s) - medicine , azotemia , cats , kidney disease , gastroenterology , endocrinology , renal function
Background Currently, no test can accurately predict the development of azotemia after treatment of hyperthyroidism. Serum cystatin C concentrations ( sC ysC) might be less influenced by changes in body muscle mass and so better indicate the presence of concurrent chronic kidney disease ( CKD ) in hyperthyroidism. Hypotheses sC ysC will be higher in hyperthyroid cats that develop azotemia compared with hyperthyroid cats that remain nonazotemic after treatment; sC ysC will be higher in nonhyperthyroid cats with azotemic CKD than healthy older cats and, sC ysC will decrease after treatment of hyperthyroidism. Animals Ninety‐one cats treated in first opinion practice. Methods Case–control study. sC ysC were compared between hyperthyroid cats which developed azotemia within 4 months of successful treatment of hyperthyroidism (pre‐azotemic group) and hyperthyroid cats which remained nonazotemic after treatment (nonazotemic group), and between nonhyperthyroid cats with azotemic CKD and healthy older cats. sC ysC were also compared between hyperthyroid cats before treatment and at time of establishment of euthyroidism. Data are presented as median [25th, 75th percentile]. Results Baseline sC ysC were not different between the pre‐azotemic and nonazotemic groups (1.9 [1.4, 2.3] mg/L versus 1.5 [1.1, 2.2] mg/L, respectively; P = .22). sC ysC in nonhyperthyroid cats with azotemic CKD and healthy older cats were not significantly different (1.5 [1.0, 1.9] mg/L versus 1.2 [0.8, 1.4] mg/L, respectively; P = .16). sC ysC did not change significantly after treatment of hyperthyroidism (pretreatment 1.8 [1.2, 2.3] mg/L, after treatment 1.6 [1.1, 2.4] mg/L; P = .82). Conclusions and Clinical Importance sC ysC do not appear to be a reliable marker of renal function in hyperthyroid cats.