English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Background  Pleural effusion is a common cause of dyspnea in cats. N‐terminal pro‐B‐type natriuretic peptide ( NT ‐pro BNP ) measurement, using a first‐generation quantitative  ELISA , in plasma and pleural fluid differentiates cardiac from noncardiac causes of pleural effusion.    Hypothesis/Objectives  To determine whether  NT ‐pro BNP  measurements using second‐generation quantitative  ELISA  and point‐of‐care ( POC ) tests in plasma and pleural fluid distinguish cardiac from noncardiac pleural effusions and how results compare to the first‐generation  ELISA .    Animals  Thirty‐eight cats ( US  cohort) and 40 cats ( UK  cohort) presenting with cardiogenic or noncardiogenic pleural effusion.    Methods  Prospective cohort study. Twenty‐one and 17 cats in the  US  cohort, and 22 and 18 cats in the  UK  cohort were classified as having cardiac or noncardiac pleural effusion, respectively. NT‐proBNP concentrations in paired plasma and pleural fluid samples were measured using second‐generation  ELISA  and  POC  assays.    Results  The second‐generation  ELISA  differentiated cardiac from noncardiac pleural effusion with good diagnostic accuracy (plasma: sensitivity, 95.2%, specificity, 82.4%; pleural fluid: sensitivity, 100%, specificity, 76.5%). NT‐proBNP concentrations were greater in pleural fluid (719 pmol/L (134–1500)) than plasma (678 pmol/L (61–1500),  P  = 0.003), resulting in different cut‐off values depending on the sample type. The  POC  test had good sensitivity (95.2%) and specificity (87.5%) when using plasma samples. In pleural fluid samples, the  POC  test had good sensitivity (100%) but low specificity (64.7%). Diagnostic accuracy was similar between first‐ and second‐generation  ELISA  assays.    Conclusions and clinical importance  Measurement of  NT ‐pro BNP  using a quantitative  ELISA  in plasma and pleural fluid or  POC  test in plasma, but not pleural fluid, distinguishes cardiac from noncardiac causes of pleural effusion in cats.

Differentiation of Cardiac from Noncardiac Pleural Effusions in Cats using Second‐Generation Quantitative and Point‐of‐Care NT ‐pro BNP Measurements