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Background  Canine epileptoid cramping syndrome ( CECS ) is a paroxysmal movement disorder of Border Terriers ( BT s). These dogs might respond to a gluten‐free diet.    Objectives  The objective of this study was to examine the clinical and serological effect of a gluten‐free diet in  BT s with  CECS .    Animals  Six client‐owned  BT s with clinically confirmed  CECS .    Methods  Dogs were prospectively recruited that had at least a 6‐month history of  CECS  based on the observed phenomenology (using video) and had exhibited at least 2 separate episodes on different days. Dogs were tested for anti‐transglutaminase 2 ( TG 2 IgA) and anti‐gliadin ( AGA  IgG) antibodies in the serum at presentation, and 3, 6, and 9 months after the introduction of a gluten‐free diet. Duodenal biopsies were performed in 1 dog.    Results  Serum  TG 2 IgA titers were increased in 6/6  BT s ( P  =   .006) and  AGA  IgG titers were increased in 5/6  BT s at presentation compared to those of controls ( P  =   .018). After 9 months, there was clinical and serological improvement in all  BT s with  CECS  strictly adhering to a gluten‐free diet (5/5). One dog had persistently increased antibody titers. This dog scavenged horse manure. On the strict introduction of a gluten‐free diet this dog also had an improved clinical and serological response. The diet‐associated improvement was reversible in 2 dogs on completion of the study, both of which suffered a relapse of  CECS  on the re‐introduction of gluten.    Conclusions  Canine epileptoid cramping syndrome in  BT s is a gluten‐sensitive movement disorder triggered and perpetuated by gluten and thus responsive to a gluten‐free diet.

The Clinical and Serological Effect of a Gluten‐Free Diet in Border Terriers with Epileptoid Cramping Syndrome