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Background  Serum  N ‐terminal pro‐ C ‐natriuretic peptide ( NT ‐pro CNP ) has shown promise as a diagnostic biomarker for sepsis. Its sensitivity to detect dogs with septic peritonitis ( SP ) is reportedly low, perhaps attributable to the compartmentalization of  NT ‐pro CNP  in the abdominal cavity.    Objectives  To evaluate the use of an  ELISA  for the measurement of  NT ‐pro CNP  in canine abdominal fluid and to describe the peri‐operative pattern of abdominal fluid and serum  NT ‐pro CNP  concentrations in dogs with  SP .    Animals  Five client‐owned dogs with nonseptic abdominal effusion of varying etiologies and 12 client‐owned dogs with  SP  undergoing abdominal surgery and placement of a closed‐suction abdominal drain ( CSAD ). Six dogs were included upon hospital admission; 6 were included the day after surgery.    Methods  Prospective pilot study. A commercially available  ELISA  kit was analytically validated for use on canine abdominal fluid. The  NT ‐pro CNP  concentrations were measured in the abdominal fluid of control dogs, and in serum and abdominal fluid of dogs with  SP  from admission for  CSAD  removal.    Results  In dogs with  SP , admission abdominal fluid  NT ‐pro CNP  concentrations were lower than the concurrent serum concentrations ( P  = 0.031), and lower than control canine abdominal fluid concentrations ( P  = 0.015). Postoperatively, abdominal fluid  NT ‐pro CNP  concentrations remained lower than serum concentrations ( P  < 0.050), except on day 4.    Conclusions and Clinical Importance  The  ELISA  kit was able to measure  NT ‐pro CNP  in canine abdominal fluid. In dogs with  SP , low serum  NT ‐pro CNP  concentrations cannot be explained by abdominal compartmentalization.

Serial Evaluation of Abdominal Fluid and Serum Amino‐terminal pro‐C‐type Natriuretic Peptide in Dogs with Septic Peritonitis