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Background  Exclusive feeding of an iodine‐restricted diet has been proposed as a method for controlling clinical manifestations of hyperthyroidism in hyperthyroid cats.    Objectives  To determine the effect of feeding an iodine‐restricted diet on  TT 4 concentrations and clinical signs in cats with spontaneous hyperthyroidism.    Animals  Forty‐nine client‐owned cats with spontaneous hyperthyroidism.    Methods  Retrospective case series. Hyperthyroid cats were exclusively fed a commercially available iodine‐restricted diet. Clinical response was assessed by change in weight and heart rate and serum  TT 4, blood urea nitrogen (BUN), and creatinine concentrations at various times during dietary management (21–60 days, 60–180 days).    Results  Serum  TT 4 normalized in 20/48 cats (42%) and 39/47 cats (83%) at 21–60 days and 61–180 days, respectively. Cats in which the  TT 4 concentrations were still above reference range at 21–60 days had a significantly higher starting  TT 4 than those that normalized their  TT 4 levels during the same time period ( P  = .038). Body weight did not significantly increase ( P  = .34) nor heart rate decrease ( P  = .64) during the study. There was a significant decrease in serum creatinine ( P  = .028). Cats in the low reference range for serum  TT 4 concentrations did not have a significant increase in body weight ( P  = .41) nor creatinine ( P  = .54) when compared to those with high reference range.    Conclusions and Clinical Importance  Restricted‐iodine diets were effective at maintaining serum  TT 4 concentrations within reference ranges for a majority of cats with spontaneous hyperthyroidism over 1 year, although not all clinical signs of hyperthyroidism improved.

Effect of Feeding an Iodine‐Restricted Diet in Cats with Spontaneous Hyperthyroidism