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Background  To date, epidemiological studies on degenerative mitral valve disease ( DMVD ) in dogs have largely reported referral caseloads or been limited to predisposed breeds. Analysis of primary‐care data to identify factors associated with  DMVD  would help clinicians identify high‐risk individuals and improve understanding.    Objectives  To estimate the prevalence of and identify risk factors for  DMVD  in dogs attending primary‐care veterinary practices in England.    Animals  Cases were identified within the electronic patient records of 111,967 dogs attending 93 practices. Four hundred and 5 dogs were diagnosed with  DMVD  (diagnosed cases) and a further 3,557 dogs had a heart murmur ( HM ) consistent with  DMVD  (possible cases).    Methods  Retrospective cross‐sectional study design. Prevalence was adjusted for the sampling approach. Mixed effects logistic regression models identified factors associated with  DMVD .    Results  Prevalence estimates of diagnosed  DMVD  and  HM s consistent with  DMVD  (both diagnosed and possible cases) were 0.36% (95% confidence interval [ CI ]: 0.29–0.45) and 3.54% (95%  CI : 3.26–3.84) respectively. In the multivariable analysis, males had higher odds of diagnosed  DMVD  than did females (odds ratio [ OR ] 1.40, 95%  CI : 1.12–1.74). Insured dogs had increased odds of  DMVD  compared with noninsured dogs ( OR  3.56, 95%  CI : 2.79–4.55) and dogs ≥20 kg had approximately half the odds of  DMVD  diagnosis compared with dogs <20 kg ( OR  0.51, 95%  CI : 0.36–0.74). Strong associations between a  DMVD  diagnosis and individual breeds and age were identified.    Conclusions and Clinical Importance  Degenerative mitral valve disease was a common disorder in practice‐attending dogs. Knowledge of identified risk factors for  DMVD  could improve clinical diagnosis and direct future research.

Prevalence of and Risk Factors for Degenerative Mitral Valve Disease in Dogs Attending Primary‐care Veterinary Practices in England