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Background  Intravenous plasma administration has been recommended in healthy or sick calves with failure of passive immunity.    Hypothesis  IV administered plasma‐derived immunoglobulin  G  ( I g G ) undergoes increased catabolism as reflected by a rapid decrease in serum  I g G  concentration with an increase in fecal  I g G  concentrations within 48 h.    Animals  Thirty newborn  J ersey calves. Fifteen were fed colostrum ( CL  group) and 15 were given bovine plasma  IV  ( PL  group).    Materials and Methods  Randomized clinical trial. Calves in the  CL  group were fed 3 L of colostrum once, by oroesophageal tubing. Calves in the  PL  group were given plasma  IV  at a dosage of 34 mL/kg. Serum and fecal samples were collected at 0 h, 6 h, 12 h, 48 h, 5 d, and 7 d. Serum and fecal  I g G  concentrations were determined by radial immunodiffusion.    Results  Calves in the  CL  group maintained serum  I g G  concentrations consistent with adequate transfer of immunity (≥1,000 mg/dL) throughout the study period. Calves in the  PL  group achieved median  I g G  concentrations of ≥1,000 mg/dL at 6 h but the concentrations were <1,000 mg/dL by 12 h. Calves in the  PL  group were 5 times more likely to experience mortality compared to the  CL  group (hazard ratio = 5.01). Fecal  I g G  concentrations were not different between the 2 groups during the first 48 h ( P  >   .05).    Conclusions and Clinical Importance  Catabolism of plasma derived  I g G  occurs rapidly during the first 12 h after transfusion. Fecal excretion did not explain the fate of the plasma derived  I g G .

A Randomized Clinical Trial Evaluating Metabolism of Colostral and Plasma Derived Immunoglobulin G in J ersey Bull Calves