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Not much is known regarding underlying biological pathways to adolescents’ loneliness. Insight in underlying molecular mechanisms could inform intervention efforts aimed at reducing loneliness. Using latent growth curve modeling, baseline levels and development of loneliness were studied in two longitudinal adolescent samples. Genes (  OXTR  ,   OXT ,  AVPR 1A ,   AVPR 1B ) were examined using  SNP ‐based, gene‐based, and polygenic risk score ( PRS ) approaches. In both samples,  SNP ‐ and gene‐based tests showed involvement of the   OXTR   gene in development of loneliness, though, significance levels did not survive correction for multiple testing. The  PRS  approach provided no evidence for relations with loneliness. We recommend alternative phenotyping methods, including environmental factors, to consider epigenetic studies, and to examine possible endophenotypes in relation to adolescents’ loneliness.

A SNP , Gene, and Polygenic Risk Score Approach of Oxytocin‐Vasopressin Genes in Adolescents’ Loneliness