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Background  Little is known about the effect of the type of splint material, heat‐cured PMMA (HC) or chemical‐cured PMMA (CC) on the wear of opposing tooth surfaces.    Objective  The aim of this in vitro study was to evaluate two‐body wear of dentin, enamel, glass‐ceramic or one of four resin composites when opposing splint materials, namely ProBase HC and CC.    Methods  The two‐body wear of bovine dentine, bovine enamel, glass‐ceramic IPS e.max CAD (EMAX) and four composites (Filtek Z250 [Z250], Clearfil AP‐X [AP‐X], Clearfil Majesty Posterior [CMP], Filtek Supreme XTE [FSE]) opposing three antagonists (HC and CC and stainless steel as control) were evaluated in the ACTA wear machine. In addition, all the surfaces were evaluated with scanning electron microscopy.    Results  The highest average wear was observed in the case of dentin. The lowest average wear was found EMAX. In every case—except for EMAX—the wear rate was higher with HC than with CC (all differences being statistically significant).    Conclusions  The level of wear of enamel, dentin and various resin composites was higher in contact with HC than in CC, the wear of dentin being the highest. In the case of a patient with no or little tooth wear or whose teeth are restored with composite material or glass‐ceramic, the splint HC might be preferred because of its better durability. However, when the splint is in contact with opposing dentin preservation of the dentin, CC might be the best choice.

Effects of occlusal splint therapy on opposing tooth tissues, filling materials and restorations