English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Background  The effect of calcium channel blockers (CCB) on mortality and ischaemic stroke risk in dementia patients is understudied.    Objectives  To calculate the risk of death and ischaemic stroke in dementia patients treated with CCBs, considering individual agents and dose response.    Methods  Longitudinal cohort study with 18 906 hypertensive dementia patients from the Swedish Dementia Registry (SveDem), 2008–2014. Other Swedish national registries contributed information on comorbidities, dispensed medication and outcomes. Individual CCB agents and cumulative defined daily doses (cDDD) were considered.    Results  In patients with hypertension and dementia, nifedipine was associated with increased mortality risk (aHR 1.32; CI 1.01–1.73;  P  < 0.05) compared to non‐CCB users. Patients diagnosed with Alzheimer’s dementia (AD) or dementia with Lewy bodies/Parkinson’s disease dementia (DLB‐PDD) taking amlodipine had lower mortality risk (aHR, 0.89; CI, 0.80–0.98;  P  < 0.05 and aHR 0.58; CI, 0.38–0.86;  P  < 0.01, respectively), than those taking other CCBs. Amlodipine was associated with lower stroke risk in patients with Alzheimer’s dementia compared to other CCBs (aHR 0.63; CI, 0.44–0.89;  P  < 0.05).  Sensitivity analyses with propensity score‐matched cohorts repeated the results for nifedipine (aHR 1.35; 95% CI, 1.02–1.78;  P  < 0.05) and amlodipine in AD (aHR, 0.87; CI, 0.78–0.97;  P  < 0.05) and DLB‐PDD (aHR, 0.56, 95%CI, 0.37–0.85;  P  < 0.05).    Conclusion  Amlodipine was associated with reduced mortality risk in dementia patients diagnosed with AD and DLB‐PDD. AD patients using amlodipine had a lower risk of ischaemic stroke compared to other CCB users.

Calcium channel blockers, survival and ischaemic stroke in patients with dementia: a Swedish registry study