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10% urea cream in senile xerosis: Clinical and instrumental evaluation
Author(s) -
Lacarrubba Francesco,
Verzì Anna Elisa,
Dinotta Franco,
Micali Giuseppe
Publication year - 2021
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.14093
Subject(s) - medicine , tolerability , urea , dermatology , visual analogue scale , dry skin , clinical trial , clinical efficacy , adverse effect , surgery , chemistry , organic chemistry
Background Moisturizers represent the mainstay of treatment of xerosis and related pruritus in elderly patients. Aim In this study, we evaluated the efficacy and tolerability of a 10% urea cream in patients with senile xerosis. Methods Twenty patients affected by moderate‐to‐severe xerosis of the upper or lower extremities were enrolled and instructed to apply twice daily for 2 weeks a cream containing 10% urea. Evaluation was performed at baseline and after 7 and 14 days by: clinical examination, itch assessment using a Visual Analogue Scale (VAS), and dermoscopy. Results After 7 and 14 days of treatment, the tested urea‐based cream resulted in a significant, progressive clinical improvement of xerosis and related pruritus in all patients. The clinical results were supported by dermoscopy that showed the reduction/disappearance of scales. The cream, that had a good cosmetological acceptability, was well tolerated with no report of stinging or burning and/or other side effects. Conclusions Urea confirms to represent a key molecule for the treatment of senile xerosis.