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Background  Nonsurgical fat reduction procedures using cryolipolysis and radiofrequency are among the most popular noninvasive aesthetic procedures. In a previous study, TransFORM Body Treatment (TFB) with TriHex Technology ®  (ALASTIN ®  Skincare) improved the contour and reduced skin laxity following cryolipolysis of the arms. This product is formulated using a combination of peptides and other active ingredients designed to stimulate the autophagic breakdown of lipid droplets and expedite the apoptotic process after fat reduction procedures.    Aims  To assess the changes in abdominal volume after application of TFB for 12 weeks following cryolipolysis and radiofrequency procedures.    Methods  Following abdominal cryolipolysis or radiofrequency therapy, the subjects (N = 15) received TFB product and placebo and were randomly assigned to apply to the right or left sides of the abdomen for 12 weeks. Using 3‐dimensional digital imaging analysis, subjects were evaluated at 4, 8, and 12 weeks posttreatment.    Results  Topical TFB resulted in increased volume loss, which was greater than that for placebo at weeks 4 ( P  = .0511), 8 ( P  = .0238), and 12 ( P  = .0078), respectively, and statistically significant at weeks 8 and 12. There were no reported adverse events.    Conclusion  In this study, Topical application of TFB significantly increased adipose volume loss and improved clinical outcomes of nonsurgical fat reduction procedures.

journal of cosmetic dermatology

A randomized double‐blind trial evaluating the efficacy and tolerability of topical body treatment with TriHex Technology ®  combined with abdomen cryolipolysis or radiofrequency procedures