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Neuroprotection offered by mesenchymal stem cells in perinatal brain injury: Role of mitochondria, inflammation, and reactive oxygen species
Author(s) -
Nair Syam,
RochaFerreira Eridan,
Fleiss Bobbi,
Nijboer Cora H,
Gressens Pierre,
Mallard Carina,
Hagberg Henrik
Publication year - 2021
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.15267
Subject(s) - mesenchymal stem cell , reactive oxygen species , neuroprotection , inflammation , mitochondrion , stem cell , stem cell therapy , microbiology and biotechnology , regeneration (biology) , medicine , neuroscience , biology , immunology
Abstract Preclinical studies have shown that mesenchymal stem cells have a positive effect in perinatal brain injury models. The mechanisms that cause these neurotherapeutic effects are not entirely intelligible. Mitochondrial damage, inflammation, and reactive oxygen species are considered to be critically involved in the development of injury. Mesenchymal stem cells have immunomodulatory action and exert mitoprotective effects which attenuate production of reactive oxygen species and promote restoration of tissue function and metabolism after perinatal insults. This review summarizes the present state, the underlying causes, challenges and possibilities for effective clinical translation of mesenchymal stem cell therapy.