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Activity‐dependent central nervous system myelination throughout life
Author(s) -
Faria Omar,
Gonsalvez David G.,
Nicholson Madeline,
Xiao Junhua
Publication year - 2019
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.14592
Subject(s) - neuroscience , remyelination , central nervous system , myelin , oligodendrocyte , nervous system , biology , premovement neuronal activity
Myelin, the multilayered membrane surrounding many axons in the nervous system, increases the speed by which electrical signals travel along axons and facilitates neuronal communication between distant regions of the nervous system. However, how neuronal signals influence the myelinating process in the CNS is still largely unclear. Recent studies have significantly advanced this understanding, identifying important roles for neuronal activity in controlling oligodendrocyte development and their capacity of producing myelin in both developing and mature CNS . Here, we review these recent advances, and discuss potential mechanisms underpinning activity‐dependent myelination and how remyelination may be stimulated via manipulating axonal activity, raising new questions for future research.