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Determination of dexamethasone dose for cortisol suppression in adult common marmosets ( Callithrix jacchus )
Author(s) -
Phillips Kimberley A.,
Lopez Matthew,
Salmon Adam B.,
Ross Corin.,
Abbott David H.,
Capitanio John P.
Publication year - 2022
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/jmp.12602
Subject(s) - dexamethasone , callithrix , marmoset , dexamethasone suppression test , endogeny , glucocorticoid , endocrinology , medicine , hydrocortisone , dose dependence , biology , paleontology
We conducted a dose–response study of dexamethasone to investigate an optimal dexamethasone suppression test for common marmosets. Twelve marmosets received 0.1, 0.5, or 1.0 mg/kg dexamethasone. Doses of 0.5 and 1.0 mg/kg both suppressed endogenous cortisol for at least 18 h with greater individual variability in the lower 0.5 mg/kg dose.