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CD 4 CD 8 Double Positive T cell responses during Mycobacterium tuberculosis infection in cynomolgus macaques
Author(s) -
Diedrich Collin Richard,
Gideon Hannah Priyadarshini,
Rutledge Tara,
Baranowski Tonilynn Marie,
Maiello Pauline,
Myers Amy J.,
Lin Philana Ling
Publication year - 2019
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/jmp.12399
Subject(s) - peripheral blood mononuclear cell , mycobacterium tuberculosis , immunology , bronchoalveolar lavage , immune system , tuberculosis , cytokine , context (archaeology) , t cell , lung , biology , microbiology and biotechnology , medicine , pathology , in vitro , paleontology , biochemistry
Background Tuberculosis ( TB ) kills millions of people every year. CD 4 and CD 8 T cells are critical in the immune response against TB . T cells expressing both CD 4 and CD 8 ( CD 4 CD 8 T cells) are functionally active and have not been examined in the context of TB . Methods We examine peripheral blood mononuclear cells ( PBMC ) and bronchoalveolar lavage cells ( BAL ) and lung granulomas from 28 cynomolgus macaques during Mycobacterium tuberculosis (Mtb) infection. Results CD 4 CD 8 T cells increase in frequency during early Mtb infection in PBMC and BAL from pre‐infection. Peripheral, airway, and lung granuloma CD 4 CD 8 T cells have distinct patterns and greater cytokine production than CD 4 or CD 8 T cells. Conclusion Our data suggest that CD 4 CD 8 T cells transient the blood and airways early during infection to reach the granulomas where they are involved directly in the host response to Mtb.