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ALIGNed on adherence: subanalysis of adherence in immune‐mediated inflammatory diseases in the DACH region of the global ALIGN study
Author(s) -
Kolios A.G.A.,
Hueber A.J.,
Michetti P.,
Mrowietz U.,
MustakBlagusz M.,
Sator P.G.,
Reinshagen M.,
WilsmannTheis D.,
GomisKleindienst S.,
Luckey U.,
Rössler A.,
Schiefke I.
Publication year - 2019
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/jdv.15179
Subject(s) - medicine , ankylosing spondylitis , rheumatoid arthritis , psoriatic arthritis , cohort , ulcerative colitis , psoriasis , physical therapy , disease , immunology
Background Non‐adherence to medication is a challenging problem in daily clinical practice. Objective To assess reasons for non‐adherence in patients with chronic immune‐mediated inflammatory diseases (IMIDs) in a direct comparison including evaluation of treatment necessity and concerns. Methods ALIGN was a non‐interventional, multicountry, multicentre, self‐administered, cross‐sectional, epidemiologic survey study. Here, we investigate the German, Austrian and Swiss (DACH) cohort. Six hundred thirty‐one patients with different IMIDs (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, plaque psoriasis, Crohn's disease and ulcerative colitis) under systemic therapies were evaluated concerning adherence, beliefs of necessity and concerns towards treatment in patients with IMIDs. Results The DACH cohort had significantly different levels of adherence depending on the IMID ( P < 0.05) and the type of therapy ( P < 0.05). Based on the significant influence of concerns on treatment adherence ( P < 0.05) and the high belief of treatment necessity, patients could be classified in four attitudinal segments, which were unequally distributed throughout various IMIDs. High concerns had a significant influence on non‐adherence, whereas necessity did not. Older age, female sex, TNFi mono‐, conventional combination and TNFi combination therapy are positively associated with adherence. Conclusions In the DACH region, patients are less concerned about medication and believe in the necessity of treatment. Therefore, we suggest adapting the communication in the various patient groups.