Open AccessAllogeneic islet transplantation with monitoring of islet‐specific cellular autoimmunity in a Japanese patient with type 1 diabetes: A case report
Author(s) -
Chujo Daisuke,
Kurokawa Toshiaki,
Kawabe Akitsu,
Takahashi Nobuyuki,
Inagaki Fuyuki,
Shinohara Koya,
Hagiwara Shotaro,
Edamoto Yoshihiro,
Ohmagari Norio,
Hinoshita Fumihiko,
Tajima Tsuyoshi,
Kajio Hiroshi,
Ohtsu Hiroshi,
Takemura Nobuyuki,
Matsumoto Shinichi,
Shimoda Masayuki
Publication year - 2022
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.13715
Subject(s) - islet , medicine , autoimmunity , transplantation , type 1 diabetes , islet cell transplantation , diabetes mellitus , immunology , hypoglycemia , cd8 , endocrinology , immune system
Here, we report a case of allogeneic islet transplantation in Japan. A 48‐year‐old man received intraportal islet transplantation (5,945 islet equivalent/kg), and stabilization of blood glucose levels and suppression of hypoglycemia were achieved. In the present case, we used our original assessment method to detect the responses of the recipient’s T cells to islet autoantigens over time to monitor cellular autoimmunity. Other markers could not predict graft dysfunction in advance, but our method detected the activation of islet antigen‐specific CD8 + T‐cell responses before the deterioration of pancreatic β‐cell function, indicating the possibility of the non‐invasive detection of pancreatic β‐cell damage due to recurrent autoimmunity.