Open AccessMetformin induces insulin secretion by preserving pancreatic aquaporin 7 expression in type 2 diabetes mellitus
Author(s) -
Kimura Tomohiko,
Kaneto Hideaki
Publication year - 2022
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.13709
Subject(s) - metformin , medicine , aquaporin , secretion , diabetes mellitus , endocrinology , type 2 diabetes mellitus , insulin , type 2 diabetes , physiology
In the presence of metformin, the c‐Jun‐NH2‐terminal kinase and p38 pathways in β‐cells are inhibited, resulting in preserved aquaporin 7 expression and improved glycerol influx, thus maintaining insulin secretion.