z-logo
open-access-imgOpen Access
Quantitative vibration perception threshold in assessing diabetic polyneuropathy: Should the cut‐off value be adjusted for Chinese individuals with type 2 diabetes?
Author(s) -
Liu Min,
Gao Yun,
Chen DaWei,
Lin Shuang,
Wang Chun,
Chen LiHong,
Ran XingWu
Publication year - 2021
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.13515
Subject(s) - medicine , gold standard (test) , polyneuropathy , peripheral neuropathy , nerve conduction study , diabetes mellitus , nerve conduction velocity , population , type 2 diabetes , nerve conduction , endocrinology , environmental health
Aims/Introduction To examine the performance and identify the optimal threshold of vibration perception threshold (VPT) for diagnosing diabetic polyneuropathy (DPN) in a Chinese population according to multiple definitions of DPN as gold standards. Materials and Methods VPT was determined in 421 Chinese individuals with type 2 diabetes, who simultaneously completed a questionnaire of neuropathic symptoms, and underwent the assessment of signs of peripheral neuropathy and electromyography tests. Three definitions of DPN (i.e., clinician‐diagnosed DPN, abnormal nerve conduction and confirmed DPN) were taken as reference gold standards. Results Vibration perception threshold was a specific measure for all three groups of DPN outcomes, with the highest specificity noted for clinician‐diagnosed DPN (85.1%). The specificity for abnormal nerve conduction and confirmed DPN was 77.0 and 76.6%, respectively. The sensitivity of VPT was 67.0% for clinician‐diagnosed DPN, 66.5% for abnormal nerve conduction and 67.2% for confirmed DPN. The optimal cut‐off threshold for abnormal nerve conduction, as well as confirmed DPN, was VPT >14.9 V. The specificity and sensitivity of VPT >14.9 V as the cut‐off value for clinician‐diagnosed DPN were 85.6 and 66.2%, respectively. When taking clinician‐diagnosed DPN as the gold standard, the performance of VPT for diagnosing DPN was best with an area under the curve value of 0.804. Conclusions VPT measured using the neurothesiometer had relatively high specificity and best performance for diagnosing DPN when clinician‐diagnosed DPN rather than abnormal nerve conduction was taken as the gold standard in a Chinese population. A VPT value of ≥15 V might be equally applicable for diagnosing DPN in a Chinese population.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.
Having issues? You can contact us here