Open AccessAll‐cause and cardiovascular disease mortality in underweight patients with diabetic nephropathy: BioBank Japan cohort
Author(s) -
Yokomichi Hiroshi,
Mochizuki Mie,
Hirata Makoto,
Nagai Akiko,
Kojima Reiji,
Horiuchi Sayaka,
Ooka Tadao,
Akiyama Yuka,
Shinohara Ryoji,
Miyake Kunio,
Yamagata Zentaro
Publication year - 2021
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.13483
Subject(s) - medicine , underweight , body mass index , microalbuminuria , hazard ratio , glycated hemoglobin , diabetes mellitus , diabetic nephropathy , disease , type 2 diabetes , overweight , endocrinology , confidence interval
We aimed to determine mortality risk in underweight patients with diabetic nephropathy for microalbuminuria or macroalbuminuria. We analyzed mortality and death‐cause data from BioBank Japan, with baseline years 2003–2007. We analyzed mortality rates from all causes and ischemic heart disease, according to body mass index (<18.5, 18.5–21.9, 22–24.9 and ≥25 kg/m 2 ). The mean (standard deviation) of patient age, body mass index, and glycated hemoglobin at enrollment was 61.6 years (11.7 years), 25.0 kg/m 2 (4.4 kg/m 2 ) and 7.7% (1.5%), respectively. Hazard ratios of all‐cause and ischemic heart disease mortality were highest (1.79 [ P = 0.0001] and 2.95 [ P = 0.027], respectively) in patients with body mass index <18.5 kg/m 2 , as compared with body mass index 22–24.9 kg/m 2 . All‐cause mortality risk for body mass index <18.5 kg/m 2 was similar to that for current smokers (hazard ratio 1.70, P < 0.0001). Underweight could be a predictor of mortality risk in patients with diabetic nephropathy for microalbuminuria or macroalbuminuria.