Open AccessPlasma xanthine oxidoreductase activity in Japanese patients with type 2 diabetes across hospitalized treatment
Author(s) -
Kawachi Yusuke,
Fujishima Yuya,
Nishizawa Hitoshi,
Nagao Hirofumi,
Nakamura Takashi,
Akari Seigo,
Murase Takayo,
Taya Naohiro,
Omori Kazuo,
Miyake Akimitsu,
Fukuda Shiro,
Takahara Mitsuyoshi,
Kita Shunbun,
Katakami Naoto,
Maeda Norikazu,
Shimomura Iichiro
Publication year - 2021
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.13467
Subject(s) - medicine , hypoxanthine , diabetes mellitus , aspartate transaminase , uric acid , alanine transaminase , xanthine , gastroenterology , type 2 diabetes , type 2 diabetes mellitus , endocrinology , enzyme , biochemistry , chemistry , alkaline phosphatase
Aims/Introduction Xanthine oxidoreductase (XOR) is an enzyme that catalyzes hypoxanthine and xanthine to xanthine and uric acid, respectively. Plasma XOR activity has recently been measured in humans. However, limited information is known about plasma XOR activity in patients with type 2 diabetes mellitus, and its changes after short‐term glycemic control treatment. Materials and Methods We enrolled 28 Japanese patients (10 men/18 women) with type 2 diabetes mellitus who were hospitalized to undergo medical treatment for diabetes. Plasma XOR activity, quantified using triple quadrupole mass spectrometry and liquid chromatography, and other clinical parameters were examined at admission and 2 weeks after treatment during hospitalization. Changes in plasma XOR activity after treatment during hospitalization and associated clinical parameters were assessed. Results At the time of admission, the median plasma XOR activity was 83.1 pmol/h/mL, with a wide range of 14.4–1150 pmol/h/mL. Multiple regression analysis identified serum aspartate transaminase and alanine transaminase levels as significant and independent factors correlating with the baseline plasma XOR. Two weeks of treatment during hospitalization was associated with a significant decrease in plasma XOR activity. Changes in serum aspartate transaminase were also the only significant and independent factor correlating with changes in plasma XOR activity. Conclusions A close relationship was observed between plasma XOR activity and liver transaminases in patients with type 2 diabetes mellitus, cross‐sectionally, and also across treatment during hospitalization.