Open AccessCombination therapy of trichloroacetic acid, human autologous fibroblast injection and fibroblast seeded microfibrous collagen scaffold as a novel treatment for osteomyelitis diabetic foot ulcer
Author(s) -
Nilforoushzadeh Mohammad Ali,
HeidariKharaji Maryam,
Zare Mehrak,
Zare Sona,
Baiat Tork Batool,
Jaffary Fariba
Publication year - 2021
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.13454
Subject(s) - medicine , osteomyelitis , diabetes mellitus , fibroblast , diabetic foot , diabetic foot ulcer , amputation , trichloroacetic acid , wound healing , surgery , endocrinology , cell culture , biochemistry , chemistry , biology , genetics
A severe complication associated with diabetes is diabetic foot ulcer (DFU). Most patients with DFU require amputation. Although treatment of non‐healing diabetic ulcers is challenging, the use of novel therapies can be effective. In this report, we present the case of a woman with type 2 diabetes with DFU‐related osteomyelitis, who was treated with a combination therapy of trichloroacetic acid, calcium alginate and foam dressings, human autologous fibroblast injection, and a fibroblast cell‐seeded collagen scaffold. The results showed the positive effects of combination therapy on DFU. In the initial treatment, the wound area was measured to be 14 × 7 cm 2 , with a depth of 4 cm. After 6 months, the wound was measured to be 1.5 cm 2 , showing a 90% reduction of the wound area. Overall, this combination therapy was highly effective in the treatment of DFU‐related osteomyelitis, and could markedly prevent amputation among DFU patients.