Open AccessAssociation of time in range with hemoglobin A1c, glycated albumin and 1,5‐anhydro‐ d ‐glucitol
Author(s) -
Ohigashi Mana,
Osugi Keiko,
Kusunoki Yoshiki,
Washio Kahori,
Matsutani Satoshi,
Tsunoda Taku,
Matsuo Toshihiro,
Konishi Kosuke,
Katsuno Tomoyuki,
Namba Mitsuyoshi,
Koyama Hidenori
Publication year - 2021
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.13437
Subject(s) - medicine , glycemic , glycated hemoglobin , diabetes mellitus , type 2 diabetes mellitus , confidence interval , hemoglobin , gastroenterology , type 2 diabetes , type 1 diabetes , endocrinology
Aims/Introduction Hemoglobin A1c (HbA1c), glycated albumin (GA) and 1,5‐anhydro‐ d ‐glucitol (1,5‐AG) are used as indicators of glycemic control, whereas continuous glucose monitoring (CGM) is used to assess daily glucose profiles. The aim of this study was to investigate the relationships between CGM metrics, such as time in range (TIR), and glycemic control indicators. Materials and Methods We carried out retrospective CGM and blood tests on 189 outpatients with impaired glucose tolerance ( n = 22), type 1 diabetes mellitus ( n = 67) or type 2 diabetes mellitus ( n = 100). Results In type 1 diabetes mellitus and type 2 diabetes mellitus patients, HbA1c and GA were negatively correlated with TIR, whereas 1,5‐AG was positively correlated with TIR. In type 1 diabetes mellitus patients, a TIR of 70% corresponded to HbA1c, GA and 1,5‐AG of 6.9% (95% confidence interval [CI] 6.5–7.2%), 20.3% (95% CI 19.0–21.7%) and 6.0 µg/mL (95% CI 5.1–6.9 µg/mL), respectively. In type 2 diabetes mellitus patients, a TIR of 70% corresponded to HbA1c, GA and 1,5‐AG of 7.1% (95% CI 7.0–7.3%), 19.3% (95% CI 18.7–19.9%) and 10.0 µg/mL (95% CI 9.0–11.0 µg/mL), respectively. TIR values corresponding to HbA1c levels of 7.0% were 56.1% (95% CI 52.3–59.8%) and 74.2% (95% CI 71.3–77.2%) in type 1 diabetes mellitus and type 2 diabetes mellitus patients, respectively. Conclusions The results of this study showed that the estimated HbA1c corresponding to a TIR of 70% was approximately 7.0% for both type 1 diabetes mellitus and type 2 diabetes mellitus patients, and that the estimated 1,5‐AG calculated from the TIR of 70% might be different between type 1 diabetes mellitus and type 2 diabetes mellitus patients.