Open AccessGlucagon regulates lipolysis and fatty acid oxidation through inositol triphosphate receptor 1 in the liver
Author(s) -
Hayashi Yoshitaka
Publication year - 2021
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.13315
Subject(s) - glucagon , lipolysis , medicine , endocrinology , catabolism , gluconeogenesis , glucagon receptor , glycogenolysis , biology , adipose tissue , glycogen , insulin , metabolism
Glucagon promotes hepatic glucose production, lipolysis and amino acid catabolism. Inhibition of glucagon activity, or glucagon resistance, not only lowers blood glucose levels, but also induces non‐alcoholic fatty liver disease and hyperaminoacidemia.